Given Tyson's long and extreme history of substance abuse, plus his current status as a cannabis mogul and $55,000 per month smoking habit, some viewers questioned whether "Iron Mike" was under the influence during the interview.
Upon seeing the freakish interview, fans flocked to social media to share their concerns.
After some early technical issues, Tyson greeted Morgan and Reid with an overabundance of "peace" signs before ignoring some questions and answering others in very awkward fashion.
Mike Tyson said tiredness was the reason for a freaky appearance on Good Morning Britain that left some viewers questioning if he was high on drugs - and others concerned for his wellbeing.
On an endless promotional tour before returning to the ring, Tyson was incoherent and hard to watch as he mumbled his way through an interview with hosts Piers Morgan and Susanna Reid.
Throughout that time Piers Morgan and Susanna Reid have repeatedly called it a "dereliction of their duty" not to speak to the electorate during a global pandemic. "We could see you were a bit tired! I had no monitor so I couldn't see you guys and forgot to look into camera".
Rather than pump the tires for their pay-per-view exhibition scheduled for November 28 in Los Angeles, Tyson had difficulty keeping his wits about him and at one point appeared to be asleep. It was very late in LA.
He was slurring his speech and at one point it looked like he actually fell asleep during the interview. Appreciate this news as some viewers have been concerned.