The failure of the VAR official David Coote to review Pickford's challenge on Van Dijk has angered Liverpool, sources have told ESPN, to the extent that they will demand an explanation from the Professional Game Match Officials Board (PGMOL) - the organisation in charge of referees and VAR.
Liverpool thought they'd snatched all three points right at the death, only for VAR to deem Mane as offside in the build-up despite the Senegal global looking at least level, if not onside. They got a point against the Premier League champions, who were clearly wounded by that 7-2 thrashing at Aston Villa, without being anywhere near the standards they have reached previously this season.
Everton, meanwhile, were top of the table after having won all four of their games in the top flight under Carlo Ancelotti this season.
Some impressive signings, such as the purchases of James Rodriguez and Allan, were thanks largely to the influence and pull of its new Italian coach, widely regarded as one of Europe's most astute tactical minds.
The Pickford incident came with Everton already trailing to Sadio Mane's third-minute goal, which was subsequently cancelled out by Michael Keane's first-half header.
The England global goalkeeper came charging off his line to wipe out van Dijk with a high scissor tackle inside the six yard box following a sixth minute free-kick.
Liverpool face an anxious wait to discover the extent of Virgil van Dijk's knee injury, amid fears the Dutchman is set for a lengthy spell on the sidelines. Who scores his 100th goal for Liverpool!
This game looked to be there for the taking for either side, but both teams came out in the second half looking nervous and tentative.
Everton may still be without a victory in a Merseyside derby for a decade - but they will happily take this point against Liverpool after an afternoon of chaos and controversy at Goodison Park.
With a man advantage following Richarlison's dismissal in the 90th minute, Liverpool pressed to find the victor and thought it had secured all three points at the death. Pickford leapt to his right to make a stunning save from Trent Alexander-Arnold's free-kick before Mane then had a similar chance to the opening goal only to this time skew Robertson's cross wide.