"Kevin, the doctor had to review the scan this morning, and he will be out between four and six weeks", his manager Pep Guardiolaconfirmed.
Only Phil Foden retained his place in the starting XI from the team that beat Aston Villa 2-0 in the Premier League on Wednesday.
The injury forces De Bruyne to miss crucial matches against Liverpool and Tottenham Hotspur and could prevent the Belgian from featuring in City'sChampions League clash against Borussia Monchengladbach on February 24. City eased past Birmingham City with a 3-0 win in the last round.
According to the Mirror, City will take a patient approach with the 29-year-old's recovery and will not rush him back into the side, with De Bruyne set to miss clashes against Cheltenham in the FA Cup fourth round and Premier League fixtures against West Brom, Sheffield United and Burnley.
And if that happens, the Manchester derby at the Etihad on March 6 would also become a concern.
"We play in these stadiums all our careers, we don't play in big stadiums all the time - we came from Cheltenham".
"I don't think there is anything special for them, but all the protocols are in place. You aren't going to get a Ronnie Radford scene where it's like a ploughed field", Duff said, referring to the ex-Hereford United player's FA Cup stunner against Newcastle United on a muddy pitch in 1972. Is it a special one? It is everyone for the past five seasons.
"We love this game and we change in these changing rooms for most of our careers most of the time".
Guardiola will also be without Kyle Walker for this weekend's FA Cup 4th round tie with Cheltenham.
But Guardiola was more upbeat about Walker's prospects, saying: "Kyle had a big impact kick in his hips, but it was just a kick".