Here`s how hypertensives can lower diabetes risk whilst asleep
Sep 25 2015
Adults with hypertension who do not have diabetes have a lower risk for developing the disease when taking their blood pressure medication at bedtime compared with adults who take the medication upon awakening, according to research in Diabetologia.
Researchers utilized a randomized, open-label, blinded endpoint trial of 2,012 patients with hypertension but without diabetes.
"One of the reasons why people are advised to take their blood pressuremedications in the morning is because blood pressure is normally higher during the day than at night while you're sleeping". During that time, 171 patients developed type 2 diabetes.
This first study suggested to the researchers that lowering sleep-time blood pressure could be a novel method for reducing the risk of new-onset diabetes.
"Ingesting hypertension medications at bedtime, instead of upon awakening in the morning, improves asleep BP control and markedly reduces the risk of diabetes", Ramón C. Hermida, PhD, director of the bioengineering and chronobiology laboratories at the University of Vigo, Spain, told Endocrine Today. "Maybe the ideal time for blood pressure treatment is at night." said Dr. Ramon Hermida, a professor of medicine at the University of Vigo in Spain and co-author of the study. Investigators who did not know which patients were in which group assessed the development of new-onset diabetes.
High blood pressure costs the United States an estimated $46 billion every year. The systolic pressure is the top number in a blood pressure reading. These medications modulate or block the effects of angiotensin II, a hormone that causes not only vasoconstriction and increased of blood pressure, but also contributes to increased glucose release from the liver and decreased insulin sensitivity. None of the participants had diabetes at the beginning of the trial. Those who took their medication at bedtime had significantly lower average blood pressure while asleep, and also had a heightened reduction in blood pressure.
Furthermore, the researchers discovered that "non-dippers" are at greater risk of developing type 2 diabetes, unlike healthy people with normal levels of blood pressure. People on beta blockers reduced their odds of the blood sugar disease by 65 percent when they took their medicine at night, the researchers reported.
The first paper described that lowering blood pressure during sleeping hours may be a potential target for intervention to prevent new onset of diabetes.
Findings from the new research were published online September 23 in the journal Diabetologia. Treatment at night versus morning.