The Brazilian's header was completely unchallenged as he doubled Spurs' lead.
Finally, the end is in sight for the Marathon Men.
7 - Pochettino faced a hard situation after losing Dembele right at the start, having to change his tactics and also introduce players who were meant to be resting at the end of a hectic week. Maybe for Saturday he will be available [against Crystal Palace].
Not that they'll be thinking about that when they welcome PSV Eindhoven to Wembley.
Captain Hugo Lloris has warned Tottenham they risk blowing their Premier League and Champions League hopes unless they cut out the errors after a nervy win against Wolves.
Dele Alli and Christian Eriksen may be in line for returns after missing out against Wolves at the weekend, while the defence is likely to be bolstered by Davinson Sánchez.
"When you compete at that level against Inter Milan or PSV, of course Barcelona, it is not easy to go to the next stage of the Champions League and qualify", he said.
Still, you'd have to say the Boeren have been learning fast. He and Mexican sensation Hirving Lozano should give the Spurs full-backs plenty to think about.
When I watch that video from 1960, I think always it's a very emotional video but it will be fantastic to deliver for our fans and for all the people that moment again, to repeat it here with Tottenham.
With Lloris suspended, Pochettino added: "There are three different options - Michel Vorm, Paulo Gazzaniga and Alfie Whiteman".
Wolves were awarded a penalty in the 68th minute when Jimenez was brought down in the box.
FW Harry Kane, 8 - Scored his second goal in three appearances while also forcing a number of saves from Rui Patricio, who had to produce a particularly acrobatic stop to tip a curling effort out of the top-right corner.
MF Mousa Dembele, N/R - Suffered an ankle injury inside the opening two minutes, ending his involvement. And this record would remain intact until at least the following season when he's likely to face between one-to-three new clubs from the Championship. That's no way to keep a match tight, and so another slogging contest could be in store.
The victory moved Spurs above Arsenal into 4th, while Kane'sgoal cannonballed his overall Premier League tally to 114 goals, a simply superb tally at the age of just 25.
"We have a how and this is the most important thing we have - how we do things".