DuChene competed in her first Boston Marathon in 2005, and finished the race in about three hours.
Lawrence Cherono of Kenyaemerged victorious in the men's race Monday, barely squeaking past Lelisa Desisa of Ethiopia.
Desisa had previously won in 2013 and 2015.
Linden finished in 2 hours, 27 minutes, almost 13 minutes faster than when she battled through icy rain to win in 2018.
Last year's second-place finisher, full-time nurse Sarah Sellers of Tucson, also improved her time from last year but finished 19th.
Cape Elizabeth native Joan Benoit Samuelson, 61, celebrating the 40th anniversary of her championship 1979 debut at Boston while a senior at Bowdoin College, once again wore a Bowdoin singlet and covered the familiar 26.2 miles in 3:04:00 - well within her goal of finishing within 40 minutes of her time (2:35:15) 40 years ago.
Kipkemoi was third in 2:08:07, while Kenya's Felix Kandie was fourth in 2:08:54 and Kirui fifth in 2:08:55.
Seven American runners finished in the top 20 of the men's race, with Scott Fauble leading the way in seventh place. McCormack finished in 11th with a time of 2:30.38.
After wins in Chicago and NY last year, 20-year-old Daniel Romanchuk secured men's wheelchair race victory in 1:21:36, while Switzerland's Manuela Schär was another to add to her series of World Marathon Majors wins as she won the women's wheelchair race in 1:34:19.