Mourinho confirmed that Zlatan Ibrahimovic, who has not been involved in United's last two matchday squads as he continues his recovery from a long-term cruciate knee ligament injury, has a "big chance" of featuring against City.
Gabriel Jesus said the opponents don't even try to win: "We took on teams that came with the intention of drawing, more the draw than the victory".
To figure out the XI for Wednesday is an impossible job, but we do know that Yaya Touré and Ilkay Gundogan will be replacing Silva and De Bruyne in midfield.
The French midfielder added: "People don't see this, don't speak about this, but every time we have important players that get injured when there is important games. It's a competition, you want to play against the best teams and the best players".
City have already guaranteed their advancement to the knockout stages, having secured top spot in Group F with victory of Feyenoord on matchday five, but will be looking to maintain their unbeaten start to the season. "But the teams have been playing closed, we have had difficulty finding the spaces there, because there are a lot of people in front of the box".
Angelo Ogbonna put the visitors ahead on the stroke of half-time with a firm header from a corner, further underlining a growing belief that City side can be exposed at set-pieces.
He said: "Maybe [it is] good for me to get a little bit of rest and prepare myself for Sunday". Given the amount of times they have come up with late winners recently, you would have to say the omens are good.
The incident came after Raheem Sterling's late victor sent the Etihad into pandemonium, setting them up for a record-equalling 13th consecutive Premier League victory against West Ham on Sunday.
"Of course, I was a little upset because I thought we did great and were so close to getting at least one point. We showed much better discipline as a team and now we need to move on".