Emergency services were called to Piccadilly Theatre on Denman Street shortly before 8pm on Wednesday, after part of the ceiling crashed down into the auditorium.
"Five members of the audience sustained minor injuries and were taken to local hospitals".
A picture from the Twitter feed of @KBGDunn showing the hole in the ceiling at the Piccadilly Theatre.
The production features Hollywood actor Wendell Pierce and one witness, Tracy De Groose, said the star came out to check everyone was okay.
"We are so sorry that unfortunately, this happened".
Journalist Martin George, 41, who was sitting in the grand circle, said: "About 10 minutes into the performance you could hear this slight dripping sound in the [grand] circle and people were looking around, wondering what was happening, but the play carried on".
'There had been folk screaming at that level and all americans got up and streamed down the stairs'.
Over 1,000 people have been evacuated from the venue, the Met Police said.
Following the incident, Pierce thanked audience members for a safe evacuation, apologizing for the unexpected cancellation of the performance, and urging them to come back to see the production. A few minor injuries.
'Motorists informed to spend different routes'.
In December of 2013, the ceiling of London's Apollo Theatre partially collapsed during a performance of The Curious Incident in the Dog in the Night-Time.
"We've been in close contact with emergency services who were on the scene last night to evacuate theatre patrons and treat those injured", a council statement added.