At approximately 1:08pm local time, moments after the conclusion of the national anthem, Pence tweeted that he had left the game as a result of the protests, saying he refused to "dignify any event that disrespects our soldiers, our Flag, or our National Anthem".
"While everyone is entitled to their own opinions, I don't think it's too much to ask NFL players to respect the Flag and our National Anthem", the statement opposing the protest continued.
All of the Colts players stood for the anthem, but several 49ers players knelt. Colt's players stood, linked arm-in-arm. Pence was in the crowd for the game where the Colts were honoring Peyton Manning.
Players blasted Trump via social media for his remarks.
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Pence even had a graphic all set to go for his little thread back there, which means this was most likely planned in advance. After having players kneel last week, both the Detroit Lions and Buffalo Bills all stood for the anthem before their games.
The former IN governor flew IN so he could watch Peyton Manning's jersey retirement ceremony on Sunday.
"He's not planning on kneeling.and he's planning on standing for the anthem", La Canfora said.
Critics have also said that Donald Trump and Mike Pence are trying to re-frame the protests as an act against the troops and the flag when it really started as an act of protest against police brutality against minorities. So the National Football League and the players really have to do the honor of the country.
In his explanation for leaving Sunday's game, Mr Pence stressed that he stood with Mr Trump on the issue.
Pence has followed President Trump's lead by criticizing players who do not stand for the anthem.