Academy attention will nearly certainly focus on Jennifer Lawrence who plays the title character, and through whose perspective - and on whose face - Aronofsky lingers throughout.
The blonde beauty was joined on the red carpet by her co-stars, Michelle Pfeiffer, who looked equally as lovely in a full-length diamond-patterned metallic dress, and Javier Bardem.
The movie, directed by her boyfriend Darren Aronofsky, involves a scene where she hyperventilates heavily and the actress accidentally tore her diaphragm.
Aronofsky was nominated for directing "Black Swan" (2010), another psychological thriller which won Natalie Portman an Oscar for her portrayal of a woman descending into madness, much like Lawrence's character.
Multiple attendees at the Venice press screening have reported a mixed reaction of audible boos and cheers to the film, and the first smatterings of opinions reaching the internet have proved divisive.
American chef Anthony Bourdain also went to the premiere, and he thought the film was dark, brilliant, and will upset a lot of people.
Aronofsky and Lawrence have been romantically linked since September 2016, confirming reports that they began seeing each other after the film wrapped.
For the past year, I've been dealing with him as just a human.
"I've been in relationships before where I am just confused".
In a new Vogue interview, Jennifer revealed she fell for her director while they were making mother! but she had no idea what he thought of her until filming had wrapped and the couple started quietly dating. She kicked off the day in a relatively laid-back, yet still perfectly put-together, ensemble as she arrived at the Hotel Excelsior after enjoying a scenic boat ride with Aronofsky through the historic city's canals. "I don't know how he felt about me". "But it also makes it a movie that's about everything and nothing". It opens September 15 after festival bows in Venice and Toronto.