Her late ex-boyfriend Mac Miller tragically died a year ago from an accidental overdose.
She thanked him in her acceptance speech, as well as their seven-month-old daughter, Kulture.
"I can't breathe. Oh, my goodness, child", she said as she fought back tears.
Grande seemed to hit out at Grammy producers once more when responding to a fan in another deleted tweet that read: 'THEY INVITED HIS PARENTS OUT. NO'. "Trash", she continued, and "literal bulls-". "I adored you from the day I met you when I was nineteen and I always will", she wrote.
Cardi's debut Invasion of Privacy beat out albums by the late Mac Miller, Nipsey Hussle, Pusha T and Travis Scott.
Many fans took this to be about Cardi B personally, and you'd be forgiven for thinking so, too - but that's not the case.
Miller had been nominated, and Grande had clearly been holding out for a posthumous honour.