The Cubs tied it in the third on an RBI double by Jason Heyward and a run-scoring single by Kris Bryant.
Brett Cecil then relieved and on a 3-2 pitch, Rizzo hit a looper to shallow left-center. The Cubs began the day one game behind shaky Milwaukee for the division lead, with the Cardinals 3 1/2 back of the Brewers.
Lester (7-6) had a ideal game until Wainwright singled with two outs in the sixth. He threw nine scoreless innings, allowing just four hits with a walk and 10 strikeouts.
While many fans have felt this way for some time, the Cardinals hopped on board with the idea Friday, promoting the organization's top catching prospect to the major league club to serve as the backup backstop to Yadier Molina. He hit.283 with 10 homers and 41 RBIs in 68 games with Memphis.
MARLINS 5, REDS 4 J.T. Realmuto hit a pair of two-run home runs and a double, powering visiting Miami to its second consecutive victory over slumping Cincinnati.
Roster changes may be swirling around him this week, but right-hander Adam Wainwright remains the dependable fixture for the St. Louis Cardinals. Roark tossed seven innings of two-run baseball while striking out 11 batters.
NATIONALS 4, DIAMONDBACKS 3 Bryce Harper hit a home run and drove in two runs, Tanner Roark struck out a season-high 11 and Sean Doolittle stranded the potential tying run to preserve visiting Washington's victory over Arizona.
Left fielder Kyle Schwarber bats fifth, Ian Happ is playing center and batting sixth, Addison Russell is seventh and Javier Baez is batting 8th.
While the Cardinals are now 4.5 games back and in fourth place in the tightly contested NL Central, their run differential is actually better than that of the Cubs' (+22 vs. +21). Similar to Wacha, Quintana has been much better over the past month, compiling one win in four starts with a 2.35 ERA, 1.04 WHIP, and a 12.9 K/9 rate while allowing opponents to slash.188/.258/.306. Grichuk's two-run shot in the second put the Cardinals up 2-0 while DeJong's blast in the fourth made it 3-2.
ST. PETERSBURG, Fla. - Texas turned three Tampa Bay miscues into a three-run sixth inning and the Rangers beat the Rays.
CF Dexter Fowler was 3-for-4 with a double, RBI, run scored and a stolen base Friday as he recorded his third three-hit game of the season and first since May 28.
After Paul DeJong and Randal Grichuk hit two-out homers off Lester for a 2-0 lead, the Cubs came back.
Cubs: After Hendricks (4-3, 4.09 ERA) faces RHP Miguel Gonzalez (4-9, 4.89 ERA) in the series opener, RHP John Lackey, RHP Jake Arrieta and LHP Jon Lester start the next three games against the last-place White Sox.